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020 _a9781461464648
_99781461464648
024 7 _a10.1007/9781461464648
_2doi
035 _avtls000341915
039 9 _a201509030342
_bVLOAD
_c201405050235
_dVLOAD
_y201402061113
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC321-580
100 1 _aRocha, Luisa.
_eeditor.
_965169
245 1 0 _aPharmacoresistance in Epilepsy :
_bFrom Genes and Molecules to Promising Therapies /
_cedited by Luisa Rocha, Esper A. Cavalheiro.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _axii, 329 páginas 40 ilustraciones, 26 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aPharmacoresistance and Epilepsy -- Genes involved in pharmacoresistant epilepsy -- Pathological oscillations in the pharmacoresistant epileptic brain -- Molecular mechanisms of pharmacoresistant epilepsy -- Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance -- Intracellular pathways associated with neuronal survival and death in epilepsy -- The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration -- Proteomics-based strategy to identify biomarkers and pharmacological targets in temporal lobe epilepsy -- Abnormalities of GABA system and human pharmacoresistant epilepsy -- Pharmacoresistant epilepsy and immune system -- Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy -- Experimental models to study pharmacoresistance in epilepsy -- Resistance to epileptogenesis in the Neotropical rodent Proechimys -- On the development of new antiepileptic drugs for the treatment of pharmacoresistant epilepsy – Different approaches to different hypothesis -- Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy -- Vagus Nerve Stimulation for Intractable Seizures -- The role of neuromodulation in the treatment of refractory epilepsy -- Transcranial magnetic stimulation and refractory partial epilepsy -- Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity -- Physical exercise as a strategy to reduce seizure susceptibility.
520 _aAlthough more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aCavalheiro, Esper A.
_eeditor.
_9317580
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781461464631
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-6464-8
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999 _c288041
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