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003 MX-SnUAN
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008 150903s2013 xxu| o |||| 0|eng d
020 _a9781461447443
_99781461447443
024 7 _a10.1007/9781461447443
_2doi
035 _avtls000341402
039 9 _a201509030830
_bVLOAD
_c201405050228
_dVLOAD
_y201402061058
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aR-RZ
100 1 _aHoward, Kenneth A.
_eeditor.
_9317795
245 1 0 _aRNA Interference from Biology to Therapeutics /
_cedited by Kenneth A. Howard.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2013.
300 _axv, 337 páginas 46 ilustraciones, 35 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Delivery Science and Technology,
_x2192-6204
500 _aSpringer eBooks
505 0 _aRNA Interference Pathways and Therapeutic Exploitation RNA Interference -- Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference -- The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine -- Intracellular Delivery Considerations for RNAi Therapeutics -- Mucosal Delivery of RNAi Therapeutics -- Nanomedicines for Systemic Delivery of RNAi Therapeutics -- Lipidoids: A Combinatorial Approach to siRNA Delivery -- Polymeric Micelles for siRNA Delivery -- RNAi Therapeutic Delivery by Exosomes -- Aptamer-Mediated siRNA Targeting -- RNAi as Anti-Viral Therapy: The HIV-1 Case -- Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication -- The Application of microRNAs in Cancer Diagnostics -- Therapeutic Application of miRNAs in Cancer -- Clinical Development of an Inhalable Anti-RSV siRNA Treatment.
520 _aThe Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.   Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeutics” that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-read” for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectives” section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation. “RNA Interference from Biology to Therapeutics” is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781461447436
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-4744-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c288188
_d288188