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020 _a9781461450375
_99781461450375
024 7 _a10.1007/9781461450375
_2doi
035 _avtls000341497
039 9 _a201509030329
_bVLOAD
_c201405050229
_dVLOAD
_y201402061101
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRB155-155.8
100 1 _aSpies, Maria.
_eeditor.
_9317867
245 1 0 _aDNA Helicases and DNA Motor Proteins /
_cedited by Maria Spies.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _axii, 299 páginas 69 ilustraciones, 58 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v973
500 _aSpringer eBooks
505 0 _aPreface -- Overview: What are DNA helicases? -- Structure and mechanisms of SF1 DNA helicases -- Structure and mechanisms of SF2 DNA helicases -- Structure and mechanisms of hexameric helicases -- Helicases at the replication fork -- DNA helicases associated with genetic instability, cancer and aging -- The Helicase-primase complex as a target for effective herpesvirus antivirals -- RecQ helicases - conserved guardians of genetic integrity -- Roles of DNA helicases in the mediation and rRegulation of homologous recombination -- DNA helicases in NER, BER and MMR -- Roles for helicases as ATP-dependent molecular switches -- The FtsK family of DNA pumps -- ATP dependent chromatin remodelers -- Index.
520 _aIn recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781461450368
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-5037-5
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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