000 03952nam a22003735i 4500
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008 150903s2012 xxu| o |||| 0|eng d
020 _a9781461435730
_99781461435730
024 7 _a10.1007/9781461435730
_2doi
035 _avtls000341041
039 9 _a201509030831
_bVLOAD
_c201405050222
_dVLOAD
_y201402061050
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRB155-155.8
100 1 _aKadenbach, Bernhard.
_eeditor.
_9318825
245 1 0 _aMitochondrial Oxidative Phosphorylation :
_bNuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology /
_cedited by Bernhard Kadenbach.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _axI, 372 páginas 33 ilustraciones, 26 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v748
500 _aSpringer eBooks
505 0 _aPreface -- Introduction -- Mitochondrial Dynamics: The Intersection of Form and Function -- Biogenesis of Mitochondrial Proteins -- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology -- Supramolecular Organization of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation -- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain -- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins -- Evolution of the Couple Cytochrome C and Cytochrome C Oxidase in Primates -- Reaction Mechanism of Mammalian Mitochondrial Cytochrome C Oxidase -- Phosphorylation of Mammalian Cytochrome C and Cytochrome C Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease -- Individual Biochemical Behavior Versus Biological Robustness: Spotlight on the Regulation of Cytochrome C Oxidase -- Bigenomic Regulation of Cytochrome C Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism -- Cytochrome C Oxidase and its Role in Neurodegeneration and Neuroprotection -- The Many Clinical Faces of Cytochrome C Oxidase Deficiency -- Index.
520 _aThis book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781461435723
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-3573-0
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c288877
_d288877