000			04480nam a22003975i 4500
001			288944
003			MX-SnUAN
005			20160429154651.0
007			cr nn 008mamaa
008			150903s2012 xxu| o |||| 0|eng d
020			_a9781461415428 _99781461415428
024	7		_a10.1007/9781461415428 _2doi
035			_avtls000340617
039		9	_a201509030826 _bVLOAD _c201404300418 _dVLOAD _y201402061029 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC321-580
100	1		_aAntkiewicz-Michaluk, Lucyna. _eeditor. _9318927
245	1	0	_aIsoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants : _bNew Vistas In Parkinson's Disease Therapy / _cedited by Lucyna Antkiewicz-Michaluk, Hans Rommelspacher.
250			_a1.
264		1	_aBoston, MA : _bSpringer US, _c2012.
300			_ax, 177 páginas 34 ilustraciones, 3 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aCurrent Topics in Neurotoxicity ; _v1
500			_aSpringer eBooks
505	0		_aTwo faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endogenous neurotoxin or a neuromodulator? -- Isoquinolines as a neurotoxins: action and molecular mechanism -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline – a potent neuroprotecting agent -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies -- Beta-carbolines as neurotoxins -- Neuroprotective ?-carbolines: occurrence, formation and biodegradation -- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase -- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria -- Antioxidant properties of ?-carbolines -- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies -- Prospects for new treatment options in neurodegenerative diseases.
520			_aThis book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.  Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease. The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson's Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson's disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): BCs and TIQs. These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aRommelspacher, Hans. _eeditor. _9318928
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781461415411
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-1542-8 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c288944 _d288944