000			04461nam a22003735i 4500
001			289193
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007			cr nn 008mamaa
008			150903s2008 xxu| o |||| 0|eng d
020			_a9781597453561 _99781597453561
024	7		_a10.1007/9781597453561 _2doi
035			_avtls000343069
039		9	_a201509030901 _bVLOAD _c201405050251 _dVLOAD _y201402061147 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
100	1		_aHaley, John D. _eeditor. _9319298
245	1	0	_aEGFR Signaling Networks in Cancer Therapy / _cedited by John D. Haley, William John Gullick.
264		1	_aTotowa, NJ : _bHumana Press, _c2008.
300			_axI, 395 páginas _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aCancer Drug Discovery and Development
500			_aSpringer eBooks
505	0		_aEGFR Signaling Networks -- EGFR Receptor Family Extracellular Domain Structures and Functions -- EGFR family heterodimers in cancer pathogenesis and treatment -- Structure-function of EGFR kinase domain and its inhibitors -- Internalization and degradation of EGF receptor -- Differential dependence of EGFR and ErbB2 on the molecular chaperone Hsp90 -- Activation of STATs 3 and 5 Through the EGFR Signaling Axis -- The intersection of EGFR and the Ras signaling pathway -- PHOSPHOINOSITIDE 3-KINASE ENZYMES AS DOWNSTREAM TARGETS OF THE EGF RECEPTOR -- Convergence of EGF Receptor and Src Family Signaling Networks in Cancer -- A Molecular Crosstalk between E-cadherin and EGFR Signaling Networks -- Crosstalk Between Insulin-like Growth Factor (IGF) and Epidermal Growth Factor (EGF) Receptors -- Negative regulation of signaling by the EGFR family -- Nuclear ErbB Receptors: Pathways and Functions -- Temporal Dynamics of EGF Receptor Signaling by Quantitative Proteomics -- Computational and Mathematical Modelling of the EGF Receptor System -- EGFR in Tumorigenesis and EGFR Tyrosine Kinase Inhibitors in Cancer Therapy -- Expression and prognostic significance of the EGFR in solid tumors -- Signalling by the EGF receptor in human cancers: accentuate the positive, eliminate the negative -- EGFR signaling in invasion, angiogenesis and metastasis -- Constitutive activation of truncated EGF receptors in glioblastoma -- EGFR Mutations, Other Molecular Alterations Related To Sensitivity to EGFR Inhibitors, and Molecular Testing for EGFR-Targeted Therapies in Non-Small Cell Lung Cancer -- Crosstalk Between COX-2 and EGFR: A Potential Therapeutic Opportunity -- Cellular sensitivity to EGF receptor inhibitors -- Utilizing combinations of molecular targeted agents to sensitize tumor cells to EGFR inhibitors.
520			_aThe epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aGullick, William John. _eeditor. _9319299
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781588299482
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-59745-356-1 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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