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008 150903s2010 xxu| o |||| 0|eng d
020 _a9781607612803
_99781607612803
024 7 _a10.1007/9781607612803
_2doi
035 _avtls000343330
039 9 _a201509030846
_bVLOAD
_c201405050255
_dVLOAD
_y201402061153
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC321-580
100 1 _aAnnunziato, Lucio.
_eeditor.
_9317967
245 1 0 _aNew Strategies in Stroke Intervention :
_bIonic Transporters, Pumps, and New Channels /
_cedited by Lucio Annunziato.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2010.
300 _axv, 254 páginas 12 ilustraciones, 6 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aContemporary Neuroscience
500 _aSpringer eBooks
505 0 _aBasis of Ionic Dysregulation in Cerebral Ischemia -- Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy? -- Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia -- Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke -- The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia -- The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia -- The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia -- The Na + /K + -ATPase as a Drug Target for Ischemic Stroke -- Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment -- Role of TRPM7 in Ischemic CNS Injury -- Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury -- The Diverse Roles of K + Channels in Brain Ischemia -- Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke.
520 _aIschemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. It will be a useful tool for researchers working in this field, and any student interested in the physiological, pathophysiological, and pharmacological features of stroke damage. About the Editor: Lucio Annunziato is a professor of pharmacology in the School of Medicine at the University of Naples ‘‘Federico II’’, Italy. He is coordinator of the University's neuroscience Ph.D. program and director of the Department of Neuroscience. He is also the president elect of the Italian Society of Neuroscience. Dr. Annunziato has authored more than 150 full papers and his scientific interest is mainly devoted to the molecular pharmacology of plasma membrane transporters and ionic channels involved in the pathophysiology of stroke. Most of his recent papers have appeared in the most qualified international journals in the field of ischemic neurodegeneration.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781607612797
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-60761-280-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999 _c289511
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