000 03877nam a22003735i 4500
001 289782
003 MX-SnUAN
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007 cr nn 008mamaa
008 150903s2008 xxu| o |||| 0|eng d
020 _a9781597453363
_99781597453363
024 7 _a10.1007/9781597453363
_2doi
035 _avtls000343059
039 9 _a201509030901
_bVLOAD
_c201405050251
_dVLOAD
_y201402061146
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aFojo, Tito.
_eeditor.
_9320160
245 1 4 _aThe Role of Microtubules in Cell Biology, Neurobiology, and Oncology /
_cedited by Tito Fojo.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2008.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aCancer Drug Discovery and Development
500 _aSpringer eBooks
505 0 _aAn Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly -- Molecular Mechanisms of Microtubule Acting Cancer Drugs -- Microtubule Dynamics -- Microtubule-Associated Proteins and Microtubule-Interacting Proteins -- The Post-Translational Modifications of Tubulin -- The Isotypes of Tubulin -- The Tubulin Superfamily -- Tubulin Proteomics in Cancer -- Tubulin and Microtubule Structures -- Destabilizing Agents -- Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin -- Antimicrotubule Agents That Bind Covalently to Tubulin -- Microtubule Stabilizing Agents -- Mechanisms of Resistance to Drugs That Interfere with Microtubule Assembly -- Resistance to Microtubule-Targeting Drugs -- Microtubule Stabilizing Agents in Clinical Oncology -- Investigational Anticancer Agents Targeting the Microtubule -- Microtubule Damaging Agents and Apoptosis -- Microtubule Targeting Agents and the Tumor Vasculature -- Neurodegenerative Diseases -- Structure, Function, and Regulation of the Microtubule Associated Protein Tau.
520 _aThe family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases. Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781588292940
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-59745-336-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999 _c289782
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