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001			289850
003			MX-SnUAN
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007			cr nn 008mamaa
008			150903s2010 xxu| o |||| 0|eng d
020			_a9781607614951 _99781607614951
024	7		_a10.1007/9781607614951 _2doi
035			_avtls000343352
039		9	_a201509030846 _bVLOAD _c201405050256 _dVLOAD _y201402061154 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRM1-950
100	1		_aMattson, Mark P. _eeditor. _9319859
245	1	0	_aHormesis : _bA Revolution in Biology, Toxicology and Medicine / _cedited by Mark P. Mattson, Edward J. Calabrese.
264		1	_aTotowa, NJ : _bHumana Press, _c2010.
300			_brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
500			_aSpringer eBooks
505	0		_aHormesis: What it is and Why it Matters -- Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response -- The Fundamental Role of Hormesis in Evolution -- Transcriptional Mediators of Cellular Hormesis -- The Devil is in the Dose: Complexity of Receptor Systems and Responses -- Exercise-Induced Hormesis -- Dietary Energy Intake, Hormesis, and Health -- Couch Potato: The Antithesis of Hormesis -- Hormesis and Aging -- The Hormetic Pharmacy: The Future of Natural Products and Man-Made Drugs in Disease Prevention and Treatment.
520			_aHormesis is defined as any circumstance in which exposure of a cell or organism to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book "Hormesis: A Revolution in Biology, Toxicology and Medicine" describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular underpinnings of the biphasic dose response/hormesis. The implications of the tapping of cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described. From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cardiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book. Features Groundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth. Explains why the principle of hormesis is important to our health, our environment, and the future of our planet. Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety. Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems. Illustrates how disorders such as diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses. Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aCalabrese, Edward J. _eeditor. _9299988
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781607614944
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-60761-495-1 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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