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001			293277
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008			150903s2014 sz | o |||| 0|eng d
020			_a9783034807265 _99783034807265
024	7		_a10.1007/9783034807265 _2doi
035			_avtls000345377
039		9	_a201509030412 _bVLOAD _c201405050320 _dVLOAD _y201402061335 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aQH506
100	1		_aMartin, Stefan F. _eeditor. _9325735
245	1	0	_aT Lymphocytes as Tools in Diagnostics and Immunotoxicology / _cedited by Stefan F. Martin.
264		1	_aBasel : _bSpringer Basel : _bImprint: Springer, _c2014.
300			_avI, 184 páginas 27 ilustraciones, 21 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aExperientia Supplementum, _x1023-294X ; _v104
500			_aSpringer eBooks
505	0		_aThe use of T cells in Hazard Characterization of Chemical and Drug Allergens and integration in testing strategies -- Activation of the TCR complex by peptide-MHC and superantigens -- Activation of the TCR complex by small chemical compounds -- T Cell Responses to Contact Allergens -- Contact hypersensitivity: Quantitative aspects, susceptibility and risk factors -- Tools and methods for identification and analysis of rare antigen-specific T lymphocytes -- Human T cell priming assay. Depletion of peripheral blood lymphocytes in CD25+ cells improves the in vitro detection of weak allergen-specific T cells -- Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity -- On the role of co-inhibitory molecules in dendritic cell – T helper cell co-culture assays aimed to detect chemical induced contact allergy -- T cell responses to drugs and drug metabolites -- Hypersensitivity reactions to betalactams.
520			_aThis book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9783034807258
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-0348-0726-5 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c293277 _d293277