000			03088nam a22003735i 4500
001			293309
003			MX-SnUAN
005			20160429155100.0
007			cr nn 008mamaa
008			150903s2012 sz | o |||| 0|eng d
020			_a9783034803649 _99783034803649
024	7		_a10.1007/9783034803649 _2doi
035			_avtls000345297
039		9	_a201509030411 _bVLOAD _c201405050319 _dVLOAD _y201402061333 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC321-580
100	1		_aGupta, Satya Prakash. _eeditor. _9325798
245	1	0	_aMatrix Metalloproteinase Inhibitors : _bSpecificity of Binding and Structure-Activity Relationships / _cedited by Satya Prakash Gupta.
264		1	_aBasel : _bSpringer Basel, _c2012.
300			_ax, 285 páginas 184 ilustraciones, 11 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aExperientia Supplementum, _x1023-294X ; _v103
500			_aSpringer eBooks
505	0		_aMatrix Metalloproteinases -- Specificity of Binding with Matrix Metalloproteinases -- The Gelatinases and Their Inhibitors: The Structure–Activity Relationships -- Advances in Studies on Collagenase Inhibitors -- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors -- Quantitative Structure–Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors -- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease.
520			_aMatrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases.   The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9783034803632
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-0348-0364-9 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c293309 _d293309