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020 _a9783211990797
_99783211990797
024 7 _a10.1007/9783211990797
_2doi
035 _avtls000345511
039 9 _a201509030413
_bVLOAD
_c201405050321
_dVLOAD
_y201402061338
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040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQD146-197
100 1 _aAldrich-Wright, Janice.
_eeditor.
_9325820
245 1 0 _aMetallointercalators :
_bSynthesis and Techniques to Probe Their Interactions with Biomolecules /
_cedited by Janice Aldrich-Wright.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2011.
300 _axxviii, 427 páginas 120 ilustraciones, 40 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aIntroduction -- Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers -- Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing.
520 _aA comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783211094273
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-211-99079-7
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999 _c293321
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