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001			293979
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008			150903s2005 gw | o |||| 0|eng d
020			_a9783540267652 _99783540267652
024	7		_a10.1007/b138038 _2doi
035			_avtls000346713
039		9	_a201509031116 _bVLOAD _c201405070509 _dVLOAD _y201402070904 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aQR355-502
100	1		_aEnjuanes, Luis. _eeditor. _9327128
245	1	0	_aCoronavirus Replication and Reverse Genetics / _cedited by Luis Enjuanes.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2005.
300			_axI, 257 páginas 49 ilustraciones _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v287
500			_aSpringer eBooks
505	0		_aCoronavirus Genome Structure and Replication -- Coronavirus Transcription: A Perspective -- The Coronavirus Replicase -- Viral and Cellular Proteins Involved in Coronavirus Replication -- Coronavirus Reverse Genetics by Targeted RNA Recombination -- Coronavirus Reverse Genetics and Development of Vectors for Gene Expression -- Reverse Genetics of Coronaviruses Using Vaccinia Virus Vectors -- Development of Mouse Hepatitis Virus and SARS-CoV Infectious cDNA Constructs.
520			_aCoronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9783540214946
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/b138038 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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