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020 _a9783540277026
_99783540277026
024 7 _a10.1007/3540277021
_2doi
035 _avtls000347023
039 9 _a201509030734
_bVLOAD
_c201404121319
_dVLOAD
_c201404091057
_dVLOAD
_y201402070922
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQR180-189.5
100 1 _aCompans, R.W.
_eeditor.
_9327323
245 1 0 _aCD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential /
_cedited by R.W. Compans, M.D. Cooper, T. Honjo, H. Koprowski, F. Melchers, M.B.A. Oldstone, S. Olsnes, M. Potter, P.K. Vogt, H. Wagner, Bruno Kyewski, Elisabeth Suri-Payer.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _axI, 330 páginas 22 ilustraciones
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v293
500 _aSpringer eBooks
505 0 _aOrigin and Generation -- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides -- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology -- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection -- Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models -- Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets -- Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells -- Dendritic Cells: Key Cells for the Induction of Regulatory T Cells? -- Involvement of Disease Models -- Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression -- Regulatory T Cells in Experimental Colitis -- Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control -- Regulatory T Cells in Transplantation Tolerance -- CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation -- Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity -- Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells.
520 _aThe vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aCooper, M.D.
_eeditor.
_9327324
700 1 _aHonjo, T.
_eeditor.
_9327325
700 1 _aKoprowski, H.
_eeditor.
_953448
700 1 _aMelchers, F.
_eeditor.
_9327326
700 1 _aOldstone, M.B.A.
_eeditor.
_958342
700 1 _aOlsnes, S.
_eeditor.
_9327327
700 1 _aPotter, M.
_eeditor.
_953177
700 1 _aVogt, P.K.
_eeditor.
_9327328
700 1 _aWagner, H.
_eeditor.
_9327329
700 1 _aKyewski, Bruno.
_eeditor.
_9327330
700 1 _aSuri-Payer, Elisabeth.
_eeditor.
_9327331
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783540244448
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/3-540-27702-1
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c294084
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