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020 _a9783540460916
_99783540460916
024 7 _a10.1007/9783540460916
_2doi
035 _avtls000349591
039 9 _a201509030453
_bVLOAD
_c201405050346
_dVLOAD
_y201402071206
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC254-282
100 1 _aDietel, Manfred.
_eeditor.
_9332155
245 1 0 _aTargeted Therapies in Cancer /
_cedited by Manfred Dietel.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2007.
300 _axiv, 262 páginas 57 ilustraciones
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aRecent Results in Cancer Research,
_x0080-0015 ;
_v176
500 _aSpringer eBooks
505 0 _aPrediction of Tumor Behavior -- Beyond Typing and Grading: Target Analysis in Individualized Therapy as a New Challenge for Tumour Pathology -- Oncogenic Signaling Pathways and Deregulated Target Genes -- Predictive Pathology of Cytostatic Drug Resistance and New Anti-cancer Targets -- Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract -- Resistance-Associated Signatures in Breast Cancer -- Resistance to Chemotherapy in Ovarian Carcinoma -- Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer -- Prediction of Efficacy and Side Effects of Chemotherapy in Colorectal Cancer -- Proteomic Expression Profiling of Breast Cancer -- Targeted Therapy and Clinical Applications -- Targeted Therapy and Blood-Brain Barrier -- Cetuximab: Appraisal of a Novel Drug Against Colorectal Cancer -- C-kit, GIST, and Imatinib -- Antibody Therapy in Non-Hodgkin’s Lymphoma: The Role of Rituximab, 90Y-Ibritumomab Tiuxetan, and Alemtuzumab -- Molecular and Clinical Aspects of Proteasome Inhibition in the Treatment of Cancer -- Individualized Target Therapy of Malignant Lymphomas: An Outlook -- Antiangiogenesis, Anti-VEGF(R) and Outlook -- Morphological Detection of Hormone and Growth Factor Receptors in Breast Cancer -- Prospects for Development -- Antigen-Specific Cancer Vaccines -- Therapeutic Vaccination for the Treatment of Malignant Melanoma -- Monoclonal and Recombinant Antibodies with T Cell Receptor-Like Reactivity -- New Molecular Therapy Targets in Acute Myeloid Leukemia.
520 _aFrom its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783540460909
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-540-46091-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c296814
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