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008 150903s2006 gw | o |||| 0|eng d
020 _a9783540376330
_99783540376330
024 7 _a10.1007/354037633-X
_2doi
035 _avtls000349331
039 9 _a201509030446
_bVLOAD
_c201404121539
_dVLOAD
_c201404091317
_dVLOAD
_y201402071159
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQH345
100 1 _aBerger, S. L.
_eeditor.
_9332213
245 1 4 _aThe Histone Code and Beyond :
_bNew Approaches to Cancer Therapy /
_cedited by S. L. Berger, O. Nakanishi, B. Haendler.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2006.
300 _axiv, 209 páginas 36 ilustraciones
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aErnst Schering Research Foundation Workshop,
_x0947-6075 ;
_v57
500 _aSpringer eBooks
505 0 _aThe Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development -- Nucleosome Structure and Function -- The Role of Snf2-Related Proteins in Cancer -- Imitation Switch Complexes -- How Is Epigenetic Information on Chromatin Inherited After DNA Replication? -- Polycomb Silencing Mechanisms and Genomic Programming -- CpG Island Methylation and Histone Modifications: Biology and Clinical Significance -- Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae -- Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis -- Role of Ubiquitin-Like Proteins in Transcriptional Regulation -- Interplay of the SUMO and MAP Kinase Pathways.
520 _aMethylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aNakanishi, O.
_eeditor.
_9332214
700 1 _aHaendler, B.
_eeditor.
_9332215
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783540278573
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/3-540-37633-X
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c296850
_d296850