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001			298882
003			MX-SnUAN
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007			cr nn 008mamaa
008			150903s2008 gw | o |||| 0|eng d
020			_a9783540794622 _99783540794622
024	7		_a10.1007/9783540794622 _2doi
035			_avtls000351875
039		9	_a201509030450 _bVLOAD _c201405060257 _dVLOAD _y201402171147 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC321-580
100	1		_aHeida, Tjitske. _eautor _9335500
245	1	4	_aThe Subthalamic Nucleus Part II: Modelling and Simulation of Activity / _cby Tjitske Heida, Enrico Marani, Kamen G. Usunoff.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2008.
300			_brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aAdvances in Anatomy, Embryology and Cell Biology, _x0301-5556 ; _v199
500			_aSpringer eBooks
505	0		_aThe Basal Ganglia -- STN Activity Recorded in Vitro: Brain Slices -- STN Activity Recorded in Vitro: Dissociated Cell Cultures -- STN Cell Models and Simulation of Neuronal Networks -- Comparison of Part I and Part II.
520			_aThis monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aMarani, Enrico. _eautor _9327528
700	1		_aUsunoff, Kamen G. _eautor _9327648
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9783540794615
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-540-79462-2 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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