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020 _a9783642030451
_99783642030451
024 7 _a10.1007/9783642030451
_2doi
035 _avtls000353515
039 9 _a201509030507
_bVLOAD
_c201405060321
_dVLOAD
_y201402180955
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aKalthoff, Holger.
_eeditor.
_9338065
245 1 0 _aDeath Receptors and Cognate Ligands in Cancer /
_cedited by Holger Kalthoff.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2009.
300 _axiv, 280 páginas 22 ilustraciones, 11 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aResults and Problems in Cell Differentiation,
_x0080-1844 ;
_v49
500 _aSpringer eBooks
505 0 _aThe Role of TNF in Cancer -- Many Checkpoints on the Road to Cell Death:Regulation of Fas–FasL Interactions and Fas Signaling in Peripheral Immune Responses -- FasL Expression and Reverse Signalling -- Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling -- Ubiquitination and TNFR1 Signaling -- From Biochemical Principles of Apoptosis Induction by TRAIL to Application in Tumour Therapy -- Therapeutic Targeting of TWEAK/Fn14 in Cancer: Exploiting the Intrinsic Tumor Cell Killing Capacity of the Pathway -- APRIL in B-cell Malignancies and Autoimmunity -- Autophagy in Cancer and Chemotherapy -- Glucocorticoid-Mediated Apoptosis Resistance of Solid Tumors -- Targeting Death-Receptors in Radiation Therapy -- Death Ligands Designed to Kill: Development and Application of Targeted Cancer Therapeutics Based on Proapoptotic TNF Family Ligands.
520 _aDeath receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783642030444
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-642-03045-1
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c300554
_d300554