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001			301426
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007			cr nn 008mamaa
008			150903s2010 gw | o |||| 0|eng d
020			_a9783642135170 _99783642135170
024	7		_a10.1007/9783642135170 _2doi
035			_avtls000355161
039		9	_a201509030951 _bVLOAD _c201405060346 _dVLOAD _y201402191036 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aR-RZ
100	1		_aChristen, Yves. _eeditor. _9326128
245	1	0	_aNovel Insights into Adipose Cell Functions / _cedited by Yves Christen, Karine Clément, Bruce M. Spiegelman.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2010.
300			_ax, 160 páginas 34 ilustraciones, 18 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aResearch and Perspectives in Endocrine Interactions, _x1861-2253
500			_aSpringer eBooks
505	0		_aPathological Alteration of Human Adipose Tissue in Obesity -- Dynamics of Human Adipose Tissue. Regulatory Mechanisms and Consequences for Fat Cells and the Whole Body -- Metabolism of Fatty Acids in Adipocytes -- The Role of Hypoxia in Adipocyte Function and Dysfunction -- Brown Adipose Tissue In Humans: A New Target for Anti-Obesity Therapy -- Adipose Tissue Dysfunction: A Multistep Process -- Fat Cell Progenitors: Origins and Plasticity -- Transcriptional Regulation of Brown and White Adipogenesis -- Transcriptional Control of Gene Expression in Different Adipose Tissue Depots -- Epigenetic Approaches to Adipose Biology -- Metabolic and Angiogenic Consequences of the Presence or Absence of UCP1 -- Metabolic Responses to Weight Perturbation -- Understanding Causal Relationships in the Metabolic Syndrome: Recent Insights from Extreme Human Phenotypes.
520			_aObesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders. Environmental, behavioural, genetic, epigenetic and multiple biological factors interact to cause obesity. In this context adipose tissue depots have been under focus in the last decades and pivotal concepts have emerged from the studies of their complex biology. While the white adipose tissue (WAT) is the main energy repository in the body (mobilizing fatty acids according to body needs) thanks to white adipocyte properties, WAT is also a multicellular organ communicating with other body organs (brain, muscles, liver, pancreas, heart, vessels, etc…) via complex networks of endocrine signals. The discovery of leptin in 1994 led to recognize WAT as a master organ at the crossroad of a myriad of physiological interactions to control food intake, energy balance, glucose and lipid metabolism, immunity and reproduction. The phenotype, amount and biology of each WAT component are profoundly altered in human obesity. Adipose plasticity also accounts for the extraordinary capacity of adipose precursors to differentiate into functional cardiomyocytes, osteoblasts, haematopoietic and neural cells, a convenient property for regenerative medicine. Finally, while initially thought to exert a negligible role in humans, the discovery of brown adipose tissue in adults stimulates a novel interest for this tissue with high capacity to oxidize fatty acids
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aClément, Karine. _eeditor. _9339276
700	1		_aSpiegelman, Bruce M. _eeditor. _9339277
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9783642135163
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-642-13517-0 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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