000 04562nam a22003735i 4500
001 302962
003 MX-SnUAN
005 20160429155806.0
007 cr nn 008mamaa
008 150903s2011 gw | o |||| 0|eng d
020 _a9783642160776
_99783642160776
024 7 _a10.1007/9783642160776
_2doi
035 _avtls000355908
039 9 _a201509030943
_bVLOAD
_c201405060357
_dVLOAD
_y201402191205
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRG133.5
100 1 _aSpanel-Borowski, Katharina.
_eautor
_9341453
245 1 0 _aFootmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells /
_cby Katharina Spanel-Borowski.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _axv, 110 páginas 33 ilustraciones, 22 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v209
500 _aSpringer eBooks
505 0 _a1 Background -- 1.1 Innate Immunity, Toll-like Receptors (TLR), and Danger Signals 1.2 The Ovary, Tissue Remodelling, and Immune Privilege -- 1.3 Design -- 2 Material and Methods -- 2.1 Cyclic and Superovulated Ovaries from Rats, Hamsters, Rabbits as well as Canine, Bovine and Human Ovaries -- 2.1.1 Fibrinolytic Activity and Implants on the Chick Chorioallantois Membrane (CAM) -- 2.1.2 Fixation, Staining and Counting Ovarian Structures -- 2.2 Cell Culture Subtypes from Follicles Derived from Patients Under in Vitro Fertilization Therapy -- 2.3 Cell Culture Subtypes from Bovine Corpus Luteum (CL) and Characterization -- 3 Footmarks of Innate Immunity -- 3.1 The Complement System as Danger Sensor in General and in the Ovary -- 3.2 Mild Danger with Mild Response -- 3.2.1 Implantation of the Ovary into the CAM -- 3.2.2 Follicular Atresia -- 3.3 Moderate Danger by Preovulatory Follicle Rupture and Acute Inflammation with Eosinophils -- 3.3.1 Recruitment of Eosinophils and Substance P-Like Expression -- 3.4 Severe Danger in Superovulated Ovaries with Intra-Ovarian Oocyte Release and Thrombus Formation -- 4 Cytokeratin-Positive (CK+) cell as Potential Dendritic Cells -- 4.1 Dendritic cells, the TLR System in General and in the Ovary -- 4.2 Localisation of CK+ Cells in the Intact Ovary -- 4.2.1 Follicles in Foetal and Adult Ovaries -- 4.2.2 Corpus Luteum -- 5 Characterization of Isolated CK+ Cells -- 5.1 CK+ Cells from Preovulatory Follicles with TLR4 Expression -- 5.2 CK+ Cells from CL in Comparison to CK-Negative (CK-) Cells -- 5.2.1 Effects of Interferon-gamma on CK+ Cells from the CL Compared to CK- Cells and to Surface Epithelial Cells -- 5.2.2 Reflections on Quality of the CK+ Type 1 and Similarity with the Type 5 -- 6 Working Hypothesis and Challenges -- 7 Clinical Perspectives -- 8 Concluding Summary and Remarks -- References -- Subject index.
520 _aThe cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK+) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK+ cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783642160769
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-642-16077-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c302962
_d302962