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008 150903s2012 gw | o |||| 0|eng d
020 _a9783642216497
_99783642216497
024 7 _a10.1007/9783642216497
_2doi
035 _avtls000357201
039 9 _a201509030556
_bVLOAD
_c201405070212
_dVLOAD
_y201402191310
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQH573-671
100 1 _aDenman, Robert B.
_eeditor.
_9343013
245 1 0 _aModeling Fragile X Syndrome /
_cedited by Robert B. Denman.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _axii, 392 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aResults and Problems in Cell Differentiation,
_x0080-1844 ;
_v54
500 _aSpringer eBooks
505 0 _aIntroduction: Reminiscing on Models and Modeling -- Probing Astrocyte Function in Fragile X Syndrome -- Neural Stem Cells -- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System -- The role of the postsynaptic density in the pathology of the fragile X syndrome -- Behavior in a Drosophila model of Fragile X -- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome -- Fragile X Mental Retardation Protein and Stem Cells -- Manipulating the Fragile Mental Retardation Proteins in the frog -- Exploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndrome -- Neuroendocrine alterations in the fragile X mouse -- Taking STEPs forward to understanding Fragile X Syndrome -- Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental disease -- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome -- Clinical Aspects of the Fragile X Syndrome -- Fragile X Syndrome: A Psychiatric Perspective -- Fragile X Syndrome and Targeted Treatment Trials -- The Fragile X-associated Tremor Ataxia Syndrome -- Vignettes: Models in Absentia.
520 _aThe present book is an in-depth synopsis of recent advances in the fragile X field. The fragile X syndrome (FXS) is the most common form of inherited mental retardation, and the molecular-genetic basis of this syndrome has been the subject of extensive experimental scrutiny over the last two decades. This book covers the spectrum of current FXS research, ranging from Drosophila model systems via mouse models to clinical and psychiatric aspects. The volume also provides updates on FXS-related diseases such as the fragile X-associated tremor/ataxia syndrome. Significant progress in recent years, as highlighted here by some of the most eminent researchers in the field, are grounds for optimism that successful therapeutical approaches may be feasible in the not too distant future.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783642216480
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-642-21649-7
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c304219
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