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001 306151
003 MX-SnUAN
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007 cr nn 008mamaa
008 150903s2013 gw | o |||| 0|eng d
020 _a9783642279287
_99783642279287
024 7 _a10.1007/9783642279287
_2doi
035 _avtls000358613
039 9 _a201509030607
_bVLOAD
_c201405070233
_dVLOAD
_y201402191525
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC321-580
100 1 _aMorimoto, Richard I.
_eeditor.
_9345346
245 1 0 _aProtein Quality Control in Neurodegenerative Diseases /
_cedited by Richard I. Morimoto, Yves Christen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _axii, 135 páginas 20 ilustraciones, 17 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aResearch and Perspectives in Alzheimer's Disease,
_x0945-6066
500 _aSpringer eBooks
505 0 _aThe Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.
520 _aThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aChristen, Yves.
_eeditor.
_9326128
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783642279270
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-642-27928-7
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c306151
_d306151