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008 150903s2012 au | o |||| 0|eng d
020 _a9783709110010
_99783709110010
024 7 _a10.1007/9783709110010
_2doi
035 _avtls000362605
039 9 _a201509031039
_bVLOAD
_c201405070332
_dVLOAD
_y201402211053
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQP356.3
100 1 _aLinert, Wolfgang.
_eeditor.
_9349868
245 1 0 _aMetal Ions in Neurological Systems /
_cedited by Wolfgang Linert, Henryk Kozlowski.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2012.
300 _axiv, 243 páginas 154 ilustraciones, 73 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _a1. R.R. Crichton, D.T. Dexter, R.J. Ward: Brain iron metabolism and its perturbation in neurological diseases -- 2. E. Milward et al.: Brain changes in iron loading disorders -- 3. I. Paris, J. Segura-Aguilar: The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson’s disease -- 4. E. Siakkou, G.N.L. Jameson: Iron, cysteine and neurodegeneration during Parkinson’s disease -- 5. G. Crisponi et al.: Copper uptake and trafficking in the brain -- 6. Y. Nishida: Prion diseases and manganism -- 7. A. Granzotto, P. Zatta: Metal ions and beta-amyloid: conformational modifications and biological aspects -- 8. A. Granzotto et al.: Beta-amyloid toxicity increases with hydrophobicity in the presence of metal ions -- 9. Ch. Exley, E.R. House: Aluminium in the human brain -- 10. V.M. Nurchi, G. Crisponi, V. Bertolasi, G. Faa, M. Remelli: Aluminium dependent human diseases and chelating properties of aluminium chelatots for bio-medical applications.-11. M. Suwalsky P.L. Henrnandez, C.P. Sotomayor: Aluminum increases toxic effects of amyloid beta-peptides on human erythrocyte membrane and molecular models -- 12. E. Gaggelli, G. Valensin: Oxidative stress in neurodegeneration: targeting mitochondria as a therapeutic aid -- 13. Y. Nishsida: The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders -- 14. O.G. Tsay, K. Kim, D.G. Churchil: Metal ion role in the CNS under toxic organophosphonate exposure: Traces of understanding and various open questions -- 15. S. Casito, M. Aschner: Heavy metals, behavior and neurodegeneration: Using C elegans to untangle a can of warms -- 16. C. Kallay et al.: The effect of point mutations on copper(II) complexes with peptide fragments encompassin the 106-114 region of human prion protein -- 17. E. Sija et al.: Interactions of pyridinecarboxylix acid chelators with brain metal ions: Cu(II), Zn(II), Al(III) -- 18. S. Bohic et al.: Spatially resolved imaging methods to probe metals in brain -- 19. Y. Ha, O. Tsay, D.G. Churchil: ICP-MS for the neurodegenerative and brain sciences.
520 _aMetal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aKozlowski, Henryk.
_eeditor.
_9349869
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783709110003
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-7091-1001-0
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c309564
_d309564