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020 _a9783764386986
_99783764386986
024 7 _a10.1007/9783764386986
_2doi
035 _avtls000362950
039 9 _a201509030650
_bVLOAD
_c201405070336
_dVLOAD
_y201402211135
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRM1-950
100 1 _aElliott, Steven G.
_eeditor.
_9350149
245 1 0 _aErythropoietins, Erythropoietic Factors, and Erythropoiesis :
_bMolecular, Cellular, Preclinical, and Clinical Biology /
_cedited by Steven G. Elliott, Mary Ann Foote, Graham Molineux.
250 _a2nd Revised and Extended Edition.
264 1 _aBasel :
_bBirkhäuser Basel,
_c2009.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aMilestones in Drug Therapy
500 _aSpringer eBooks
505 0 _aBackground -- Erythropoiesis: an overview -- Regulation of endogenous erythropoietin production -- Biology of erythropoietin -- Erythropoiesis—genetic abnormalities -- Erythropoiesis-stimulating agents -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin -- Commercial production of recombinant erythropoietins -- Biosimilar epoetins -- New molecules and formulations -- Erythropoietin receptor -- Structural basis for the signal transduction of erythropoietin -- Intracellular signaling by the erythropoietin receptor -- Mechanism of erythropoietin receptor activation -- Clinical utility -- Pharmacokinetics of erythropoiesis-stimulating agents -- Use of erythropoietic stimulating agents in the setting of renal disease -- Abuse of recombinant erythropoietins and blood products by athletes -- Role and regulation of iron metabolism in erythropoiesis and disease -- Nonhematopoietic effects of erythropoiesis-stimulating agents.
520 _aThis second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aFoote, Mary Ann.
_eeditor.
_9319382
700 1 _aMolineux, Graham.
_eeditor.
_9325140
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783764386948
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-7643-8698-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c309711
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