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020 _a9783764374174
_99783764374174
024 7 _a10.1007/3764374179
_2doi
035 _avtls000362747
039 9 _a201509030401
_bVLOAD
_c201404121557
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040 _aMX-SnUAN
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_cMX-SnUAN
_erda
050 4 _aR-RZ
100 1 _aZukowska, Zofia.
_eeditor.
_9350184
245 1 0 _aNPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics /
_cedited by Zofia Zukowska, Giora Z. Feuerstein.
264 1 _aBasel :
_bBirkhäuser Basel,
_c2006.
300 _aIx, 279 páginas 54 ilustraciones
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aExperientia Supplementum ;
_v95
500 _aSpringer eBooks
505 0 _aNPY family of peptides in neurobiology, cardiovascular system and metabolism: genes, diseases and therapeutics -- NPY family of peptides, receptors and processing enzymes -- An overview of neuropeptide Y: pharmacology to molecular biology and receptor localization -- Molecular ligand-receptor interaction of the NPY/PP peptide family -- Physiological and pathophysiological perspectives of the NPY family of peptides -- Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions -- NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function -- Neuropeptide Y and sympathetic control of vascular tone in hypertension -- Neuropeptide Y and the cerebral circulation -- Neuropeptide Y and the heart: implication for myocardial infarction and heart failure -- Role of neuropeptide Y in the regulation of kidney function -- NPY and neuron-adipocyte interactions in the regulation of metabolism -- NPY and energy homeostasis: an opportunity for novel anti-obesity therapies -- Subjugation of hypothalamic NPY and cohorts with central leptin gene therapy alleviates dyslipidemia, insulin resistance, and obesity for life-time -- NPY and bone -- NPY in alcoholism and psychiatric disorders -- Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis -- NPY and extreme stress: lessons learned from posttraumatic stress disorder -- NPY and chronic neurodegenerative disease -- Genetics of the NPY family of peptides and their receptors -- Human NPY gene variants in cardiovascular and metabolic diseases -- Summary -- Future directions and perspectives for therapies based on the NPY family of peptides.
520 _aThe NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine. The ideal complement to this volume is the book NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer, recently published by the same editors in the Birkhäuser book series Progress in Inflammation Research. Both volumes together give a comprehensive overview of the NPY family of peptides.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aFeuerstein, Giora Z.
_eeditor.
_9314325
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783764371555
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/3-7643-7417-9
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c309736
_d309736