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008 150903s2011 sz | o |||| 0|eng d
020 _a9783764389482
_99783764389482
024 7 _a10.1007/9783764389482
_2doi
035 _avtls000363002
039 9 _a201509031021
_bVLOAD
_c201405070338
_dVLOAD
_y201402211137
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC254-282
100 1 _aGhobrial, Irene M.
_eeditor.
_9350401
245 1 0 _aBortezomib in the Treatment of Multiple Myeloma /
_cedited by Irene M. Ghobrial, Paul G. Richardson, Kenneth C. Anderson.
264 1 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2011.
300 _aviii, 179 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aMilestones in Drug Therapy
500 _aSpringer eBooks
520 _aMultiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aRichardson, Paul G.
_eeditor.
_9350402
700 1 _aAnderson, Kenneth C.
_eeditor.
_9317258
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783764389475
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-7643-8948-2
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c309903
_d309903