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008 150903s2012 au | o |||| 0|eng d
020 _a9783709109625
_99783709109625
024 7 _a10.1007/9783709109625
_2doi
035 _avtls000362601
039 9 _a201509031039
_bVLOAD
_c201405070332
_dVLOAD
_y201402211053
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQH506
100 1 _aGroschner, Klaus.
_eeditor.
_9323783
245 1 0 _aStore-operated Ca2+ entry (SOCE) pathways :
_bEmerging signaling concepts in human (patho)physiology /
_cedited by Klaus Groschner, Wolfgang F. Graier, Christoph Romanin.
264 1 _aVienna :
_bSpringer Vienna,
_c2012.
300 _axxI, 481 páginas 56 ilustraciones, 32 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aPreface (C. Romanin, W. F. Graier, K. Groschner) -- SECTION 1: SOCE – Fundamental mechanistic concepts -- Introduction (J. W. Putney) -- 1.1 The STIM-Orai pathway -- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura) -- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan) -- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin) -- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem) -- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu) -- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca) -- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messengers and mediators (V. M. Bolotina) -- SECTION 2: SOCE – Crosstalk between organelle and cellular compartments -- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh) -- 2.1 New aspects of the contribution of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin) -- 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso) -- 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu) -- 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda) -- 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane channels by mitochondria (N. Demaurex, M. Frieden) -- 2.6 The role of mitochondria in the activation/maintenance of SOCE. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry (R. Malli, W. F. Graier) -- 2.7 Tissue specificity. The role of nanospaces between the organellar membranes in smooth muscle Ca2+ signaling (N. Fameli, A. M. Evans, C. van Breemen) -- 2.8 Tissue specificity. SOCE – implications for Ca2+ handling in endothelial cells (L. A. Blatter) -- SECTION 3: SOCE – Molecular and cellular (patho)physiology -- Introduction (J. A. Rosado) -- 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske) -- 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca2+ entry in cardiovascular disease (R. K. Motiani, M. Trebak) -- 3.3: Cardiovascular system. TRPC/Orai-containing channels, Na+/Ca2+ + exchanger and Ca2+ handling in hypertension (V. A. Golovina) -- 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito) -- 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz) -- 3.6: Cardiovascular system. SOCE and Ca2+ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado) -- 3.7: Cardiovascular system. Store-operated Ca2+ entry in endothelial pathophysiology (K. Groschner, M. Poteser) -- 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca2+ signaling (S. Bollimuntha, B. Pani, B. B. Singh) -- 3.9: Skeletal muscle. Store-operated Ca2+ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg) -- 3.10: Skeletal muscle. Store-operated channels and Ca2+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin) -- 3.11: Reproductive system. Store-operated Ca2+ entry in germ cells – role in egg activation (Z. Machaty, C. Wang, K. Lee).
520 _aStore-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aGraier, Wolfgang F.
_eeditor.
_9350709
700 1 _aRomanin, Christoph.
_eeditor.
_9350710
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9783709109618
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-3-7091-0962-5
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c310127
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