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020 _a9789048195220
_99789048195220
024 7 _a10.1007/9789048195220
_2doi
035 _avtls000365806
039 9 _a201509030657
_bVLOAD
_c201405070419
_dVLOAD
_y201402211301
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aWu, Wen-Sheng.
_eeditor.
_9355297
245 1 0 _aSignal Transduction in Cancer Metastasis /
_cedited by Wen-Sheng Wu, Chi-Tan Hu.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2010.
300 _axii, 288 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v15
500 _aSpringer eBooks
505 0 _aOverview of Signal Transduction in Tumor Metastasis -- Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways -- The ERK1/2 MAP Kinase Signaling Pathway in Tumor Progression and Metastasis -- Mitogen-Activated Protein Kinase-Activated Protein Kinases and Metastasis -- Grb2 and Other Adaptor Proteins in Tumor Metastasis -- The Role of ROS Signaling in Tumor Progression -- Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression -- Insights into the Dynamics of Focal Adhesion Protein Trafficking in Invasive Cancer Cells and Clinical Implications -- Notch Signaling in Cancer Metastasis -- New Concepts on the Critical Functions of Cancer- and Metastasis-Initiating Cells in Treatment Resistance and Disease Relapse: Molecular Mechanisms, Signaling Transduction Elements and Novel Targeting Therapies -- Involvement of Lipid Rafts in Growth Factor Receptors-Mediated Signaling for Cancer Metastasis -- Cadherin-Catenin Signaling in Ovarian Cancer Progression -- PTP4A3, a Signal Molecule Deregulated in Uveal Melanoma Metastasis -- Signal Transduction Pathways Involved in Hepatocarcinogenesis and Metastasis of Hepatoma.
520 _aThe poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aHu, Chi-Tan.
_eeditor.
_9355298
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9789048195213
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-90-481-9522-0
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c313184
_d313184