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020 _a9789400766211
_99789400766211
024 7 _a10.1007/9789400766211
_2doi
035 _avtls000367902
039 9 _a201509030719
_bVLOAD
_c201405070449
_dVLOAD
_y201402251638
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aR-RZ
100 1 _aHime, Gary.
_eeditor.
_9355816
245 1 0 _aTranscriptional and Translational Regulation of Stem Cells /
_cedited by Gary Hime, Helen Abud.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _ax, 371 páginas 61 ilustraciones, 53 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v786
500 _aSpringer eBooks
505 0 _aThe stem cell state -- Induction of pluripotency -- Germline stem cells and their regulation in the nematode Caenorhabditis elegans -- Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny -- Stem cells in the Drosophila digestive system -- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System -- Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells -- Transcriptional Regulation and Specification of Neural Stem Cells -- Transcriptional Control of Epidermal Stem Cells -- Regulation of intestinal stem cells by Wnt and Notch signalling -- Transcriptional regulation of haematopoietic stem cells -- Regulation of mesenchymal stem cell differentiation -- Molecular families implicated in stem cell regulation -- The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations -- JAK-STAT signalling in stem cells -- Myc in Stem Cell Behaviour: insights from Drosophila -- The Role of Nuclear Receptors in Embryonic Stem Cells -- Epigenetic regulation of stem cells.- Regulation of stem cell populations by microRNAs -- Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches.
520 _aStem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury.  In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced.  Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of  differentiation could disrupt tissue homeostasis or  repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and  Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of research in these rapidly evolving areas of stem cell biology to the student, educator or researcher.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aAbud, Helen.
_eeditor.
_9355817
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9789400766204
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-94-007-6621-1
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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