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008 150903s2013 ne | o |||| 0|eng d
020 _a9789400760288
_99789400760288
024 7 _a10.1007/9789400760288
_2doi
035 _avtls000367746
039 9 _a201509030717
_bVLOAD
_c201405070446
_dVLOAD
_y201402251633
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aR-RZ
100 1 _aMartin, Tracey A.
_eeditor.
_9356231
245 1 0 _aTight Junctions in Cancer Metastasis /
_cedited by Tracey A. Martin, Wen G. Jiang.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aviii, 313 páginas 46 ilustraciones, 40 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v19
500 _aSpringer eBooks
505 0 _aPreface -- The molecular aspects of Tight junctions -- The distribution of tight junctions and junctional proteins in the body -- Methodologies in investigation tight junctions -- Vascular permeability and drug delivery -- Tight junctions, BBB and brain metastasis -- Tight junctions and bladder cancer metastasis -- Tight Junctions and colorectal cancer therapies -- Tight junctions in breast cancer -- Regulation of tight junctions for therapeutic advantages -- Overcoming tight junctional permeability in cerebral metastasis -- CL-5 and cancer metastasis -- Intracellular signalling in TJ and AJ -- ROCK and TJ -- Index.
520 _aThere has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aJiang, Wen G.
_eeditor.
_9308296
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9789400760271
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-94-007-6028-8
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c313837
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