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008 150903s2013 ne | o |||| 0|eng d
020 _a9789400762176
_99789400762176
024 7 _a10.1007/9789400762176
_2doi
035 _avtls000367799
039 9 _a201509031047
_bVLOAD
_c201405070447
_dVLOAD
_y201402251635
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aShurin, Michael R.
_eeditor.
_9305070
245 1 4 _aThe Tumor Immunoenvironment /
_cedited by Michael R. Shurin, Viktor Umansky, Anatoli Malyguine.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _axvI, 745 páginas 51 ilustraciones, 46 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aPreface -- Introduction -- Role of the immunological environment in cancer initiation, development and progression -- Part I Tumor Microenvironment and Immunoenvironment -- The metastatic microenvironment -- Tumor infiltration by immune cells: pathologic evaluation and a clinical significance -- Immunologic interpretation of cancer biology: impact on clinical outcome -- Part II Developmental Characteristics of the Tumor ImmunoEnvironment -- Development of antitumor cellular immunity -- The versatile world of inflammatory chemokines in cancer.-Inflammation, Tumor Progression, and Immune Suppression -- Pleiotropic and differential functions of IL-1a and IL-1b shape the tumor microenvironment and affect the outcome of malignancies -- Impact of obesity and aging on the tumor immunoenvironment -- Part III Tumor Escape from Immune Recognition -- MHC class I antigens and the tumor microenvironment -- Tumor-produced immune regulating factors -- Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments.- T cell malfunction in the tumor environment -- Signaling of tumor-induced immunosuppression of dendritic cells -- Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells -- Part IV  Immune Regulators in the Tumor ImmunoEnvironment -- The role of myeloid-derived suppressor cells in cancer -- Macrophage differentiation and activation states in the tumor microenvironment -- Dendritic cells and cancer: development, dysfunction and therapeutic targets -- The role of tumor-associated neutrophils in cancer -- Mast cell modulation of the tumor microenvironment -- Regulatory T cells in patients with cancer -- Tumor-evoked regulatory B cells as important mediators of cancer escape -- Part V  Tumor Escape and Cancer Immunotherapy -- Cancer immunotherapy: Overview in brief -- Programming of MDSC: New opportunities for targeted therapy -- Therapeutic targeting regulatory T cells in tumor.-ChemoImmunoModulation: Focus on myeloid regulatory cells -- Combining vaccines with therapies that render tumor cells more susceptible to        immune mediated killing -- Prophylactic Cancer Vaccines -- Part VI  Analyzing Immune Responses in Cancer -- Approaches to Immunologic Monitoring of Clinical Trials -- Evaluation of the tumor immunoenvironment in clinical trials -- Analysis of Myeloid-derived Suppressor Cells in Patients with Cancer -- When results of T cell immune monitoring match or do not match clinical outcomes of tumor vaccine trials - what more could and should we measure?.
520 _aInteraction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in the tumor microenvironment. The balance between immune cells that support tumor progression and immune cells that sustain tumor-controlling immune surveillance is tightly regulated by various factors originated from both the malignant and non-cancerous cells in the tumor microenvironment. Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor ImmunoEnvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions. Moreover, it is discussed how these interactions evolve during cancer progression and in response to different kinds of anticancer therapy. It is anticipated that the book will attract many researchers and clinicians in the field of basic and applied tumor immunobiology and open new opportunities for collaborative programs aiming at the development of effective and feasible therapeutic approaches to cancer treatment.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aUmansky, Viktor.
_eeditor.
_9356238
700 1 _aMalyguine, Anatoli.
_eeditor.
_9356239
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9789400762169
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-94-007-6217-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c313842
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