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001			315412
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007			cr nn 008mamaa
008			160108s2014 xxu| s |||| 0|eng d
020			_a9781489980328 _9978-1-4899-8032-8
035			_avtls000415215
039		9	_y201601081101 _zstaff
050		4	_aRC261-271
245	1	0	_aCancer biology and the nuclear envelope : _brecent advances may elucidate past paradoxes / _cedited by Eric C. Schirmer, Jose I. de las Heras.
264		1	_aNew York, NY : _bSpringer New York : _bSpringer, _c2014.
300			_axiii, 611 páginas : _b98 ilustraciones, 84 ilustraciones en color.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v773
500			_aSpringer eBooks
505	0		_aSection I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective -- Cancer and the nuclear envelope, a history and perspective -- The role of the nuclear lamina in cancer and apoptosis -- The diagnostic pathology of the nuclear envelope in human cancers -- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer -- "To be or not to be in good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer -- Section II: The nuclear envelope in cell cycle regulation and signaling -- pRb and lamins in cell cycle regulation and aging -- Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology -- NETs and cell cycle regulation -- Nuclear envelope regulation of signaling cascades -- Section III: Nuclear envelope regulation of the genome -- Nuclear envelope - connecting structural genome organization to regulation of gene expression -- Studying lamins in invertebrate models -- Lamin organization of chromosome positioning -- Section IV: Functions of the NPC in cancer -- NPC proteins linked in cancer overview -- Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis -- Wnt signaling proteins associate with the nuclear pore complex: implications for cancer -- Section V: The nuclear envelope in DNA damage and stress responses -- DNA damage and lamins -- Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression -- Lamines and oxygen stress damage in cell proliferation.- Section VI: The nuclear envelope link to cell migration and metastasis -- Nuclear mechanics in cancer -- Nuclear envelope in nuclear positioning and cell migration -- Nesprins in cell stability and migration -- Connecting the nucleus to the cytoskeleton for nuclear positioning and call migration -- Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope -- Nuclear envelope invaginations and cancer -- Mechanisms of nuclear size regulation in model systems and cancer -- Control of nuclear size by NPC proteins -- Do lamins influence disease progression in cancer?.   .
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aSchirmer, Eric C, _eeditor. _9358164
700	1		_ade las Heras, Jose I, _eeditor. _9358165
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781489980311
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4899-8032-8 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c315412 _d315412