Activation and Detoxification Enzymes : Functions and Implications / by Chang-Hwei Chen.

Springer eBooks

Overview -- Lipophilic Foreign Compounds -- Metabolic Conversion of Lipophilic Compounds -- Phase I Enzymes -- Phase II Enzymes -- Reactive Intermediate Formation -- Biomedical and Biochemical Effects -- Genetic Variations in Metabolizing Enzymes -- Inducibility of Metabolizing Enzymes -- Induction and Inhibition Compounds -- Diets Rich in Enzyme Modulators -- Induction of Enzymes for Health Benefits -- Sources of Foreign Compounds -- Catalytic Reactions of Phase I Enzymes -- Catalytic Reactions of Phase II Enzymes -- Diversified Classes of Enzyme Modulators -- Conclusion -- Index.

There are many advances that have been made in the past decades towards the understanding of functions and implications of activation enzymes and detoxification enzymes. An organized, concise overview is needed for the readers who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology and chemistry. This book is intended to serve this purpose as an introduction to the subject. Furthermore, major topics in the book, excluding catalytic reactions and structural properties, may have interest to other readers who have knowledge of basic sciences and understanding enzyme related information. The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, phase I and phase II enzymes, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related enzyme modulators, and structural characteristics of enzyme inducers. 

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